Example Projects

Projects undertaken by the 2014/2015 ONBI cohort include:

Assessing microstructural changes in remodelling after myocardial infarction with diffusion tensor MRI

Development of imaging biomarkers for neurodegeneration using multimodal dynamic atlases

Elucidating the effect of listeria infection on neural stem cell differentiation and self-renewal using machine learning based image analysis of super-resolution images in intact live drosophila larval brain

Structural and functional connectivity of the human basal ganglia in health and disease using high resolution MRI at 7 Tesla

Approaching label-free imaging – investigation of molecular mobility and interactions using iSCAT microscopy

Unifying T1 MRI mapping methods on clinical scanners for abdominal imaging

Bimodal 1H/31P contrast agents as molecular probes for phosphate species

Investigating time-efficient methods for non-invasive brain perfusion imaging using arterial spin labelling MRI

Longitudinal facial and neuro-developmental analysis of ultrasound images in early life

Application of magnetic resonance (MR) fingerprinting to measure brain oedema

Improving reconstruction fidelity of accelerated FMRI data using generalised rank-constrained optimisation

Observations of virus-structure and virus-cell interactions using live cell super-resolution microscopy

Investigation of functional neurochemical changes during TDCS stimulation using magnetic resonance spectroscopy

RF Optimization in inhomogeneous RF Fields

Development of theranostic ultrasound-responsive contrast agents

Modelling the temporal evolution of brain activity measured using fMRI

Fractal dimension analysis of amyloid PET images in the assessment Alzheimer’s Disease

Projects undertaken by the 2015/2016 ONBI cohort include:

Using microbubble-enhanced ultrasound to better track and deliver drugs to aneurysms

Motion detection in magnetic resonance imaging

Improving the accuracy and robustness of non-invasive measurements of blood oxygenation and blood volume in stroke

Modelling the temporal evolution of brain activity measured using fMRI

Improving cancer diagnosis through computer-guided endoscopy

Abdominal imaging using ultra-high field MRI

Assessing metabolism in cerebral tumours Using hyperpolarized magnetic resonance imaging

Synthesis of a VAP-1 microbubble agent for theranostics

Human cardiac MRI at 7T using reflected power from the coil to detect motion and for cardiac gating

A multimodal temporal model of normative ageing in the brain

Integrating 3D and 2D image analysis of rare diseases

Exploring accelerated FMRI data reconstruction using extended low-rank constraints

Assessing cardiac metabolism with hyperpolarized magnetic resonance imaging

Development of a microbubble agent for detection and treatment of bladder cancer

Histology to post-mortem MRI data fusion

Determining the RF specific absorption rate (SAR) distribution for whole-body 7T MRI

Cardiac MRI image analysis: segmentation of structures and extracting active contours from 3D cardiac MRI data to assess the injection fraction

Development of longitudinal segmentation methodology for MS lesions

Development of methods for imaging oxygen extraction fraction in health and disease using MRI

Towards sub-nm precise tracking of single molecules using protein-sized silver nanoparticle labels

The development of an optically pumped magnetometer based neuroimaging system

Modelling structural and functional brain changes in disease

Projects undertaken by the 2016/2017 ONBI cohort include:

Quantification and classification of single-cell intracellular calcium responses using advanced signal processing and machine learning

Quantifying motion in cellular systems

Fluoride chelates for 18F PET imaging

Quantitative renal imaging in Chronic Kidney Disease

Passive Acoustic Mapping for Real-Time Monitoring of Non-Invasive Ultrasound Therapies

Fast dynamic microscopy of the brain

Modelling Spatio-Temporal Characteristics of Brain Changes in Disease (Subproject No. 3: Histology to post-mortem MRI data fusion)

Open source, low cost Structured Illumination Microscope

Automated predictions of Age from 2D Ultrasound Images of the Developing Brain

Interactive counting of objects in microscopy images

MR Imaging of oxygen carriers in treatment of hypoxic tumours

Analysis of MR images using machine learning

Novel approaches for 3D fluorescence cellular imaging of thick specimens such as living brains

Actin cytoskeleton-mediated force generation in cells investigated by advanced (super-resolution) microscopy

Deep tissue nanoscopy: super-resolution imaging using adaptive optics STED

Quantitative Fluorescence Microscopy for Characterisation of theranostic agents

EEG movement artifacts

Adaptive Optics in Structured Illumination Microscopy

Novel tools integrating MRI and microscopy for neuroscience

Development of methods for imaging the cerebrovasculature in health and disease using MRI

Multi-modal registration of Connectome data

Synthesis and evaluation of novel theranostic platinum anti-cancer complexes

Multiclass survival analysis on Longitudinal perinatal imaging data using deep learning and state-of-the-art inference and learning methods

Virtual histology of the human brain using MRI: Informing the brain Connectome using tissue microstructure

Dissecting antibiotic resistance and bacterial biofilms via super-resolution imaging