Example Projects

Example Projects

Projects undertaken by the 2014/2015 ONBI cohort include:

  • Assessing microstructural changes in remodelling after myocardial infarction with diffusion tensor MRI

  • Development of imaging biomarkers for neurodegeneration using multimodal dynamic atlases

  • Elucidating the effect of listeria infection on neural stem cell differentiation and self-renewal using machine learning based image analysis of super-resolution images in intact live drosophila larval brain
  • Structural and functional connectivity of the human basal ganglia in health and disease using high resolution MRI at 7 Tesla
  • Approaching label-free imaging – investigation of molecular mobility and interactions using iSCAT microscopy
  • Unifying T1 MRI mapping methods on clinical scanners for abdominal imaging
  • Bimodal 1H/31P contrast agents as molecular probes for phosphate species
  • Investigating time-efficient methods for non-invasive brain perfusion imaging using arterial spin labelling MRI
  • Longitudinal facial and neuro-developmental analysis of ultrasound images in early life
  • Application of magnetic resonance (MR) fingerprinting to measure brain oedema
  • Improving reconstruction fidelity of accelerated FMRI data using generalised rank-constrained optimisation
  • Observations of virus-structure and virus-cell interactions using live cell super-resolution microscopy
  • Investigation of functional neurochemical changes during TDCS stimulation using magnetic resonance spectroscopy
  • RF Optimization in inhomogeneous RF Fields
  • Development of theranostic ultrasound-responsive contrast agents
  • Modelling the temporal evolution of brain activity measured using fMRI
  • Fractal dimension analysis of amyloid PET images in the assessment Alzheimer’s Disease

Projects undertaken by the 2015/2016 ONBI cohort include:

  • Using microbubble-enhanced ultrasound to better track and deliver drugs to aneurysms
  • Motion detection in magnetic resonance imaging
  • Improving the accuracy and robustness of non-invasive measurements of blood oxygenation and blood volume in stroke
  • Modelling the temporal evolution of brain activity measured using fMRI
  • Improving cancer diagnosis through computer-guided endoscopy
  • Abdominal imaging using ultra-high field MRI
  • Assessing metabolism in cerebral tumours Using hyperpolarized magnetic resonance imaging
  • Synthesis of a VAP-1 microbubble agent for theranostics
  • Human cardiac MRI at 7T using reflected power from the coil to detect motion and for cardiac gating
  • A multimodal temporal model of normative ageing in the brain
  • Integrating 3D and 2D image analysis of rare diseases
  • Exploring accelerated FMRI data reconstruction using extended low-rank constraints
  • Assessing cardiac metabolism with hyperpolarized magnetic resonance imaging
  • Development of a microbubble agent for detection and treatment of bladder cancer
  • Histology to post-mortem MRI data fusion
  • Determining the RF specific absorption rate (SAR) distribution for whole-body 7T MRI
  • Cardiac MRI image analysis: segmentation of structures and extracting active contours from 3D cardiac MRI data to assess the injection fraction
  • Development of longitudinal segmentation methodology for MS lesions
  • Development of methods for imaging oxygen extraction fraction in health and disease using MRI
  • Towards sub-nm precise tracking of single molecules using protein-sized silver nanoparticle labels
  • The development of an optically pumped magnetometer based neuroimaging system
  • Modelling structural and functional brain changes in disease

Projects undertaken by the 2016/2017 ONBI cohort include:

  • Quantification and classification of single-cell intracellular calcium responses using advanced signal processing and machine learning
  • Quantifying motion in cellular systems
  • Fluoride chelates for 18F PET imaging
  • Quantitative renal imaging in Chronic Kidney Disease
  • Passive Acoustic Mapping for Real-Time Monitoring of Non-Invasive Ultrasound Therapies
  • Fast dynamic microscopy of the brain
  • Modelling Spatio-Temporal Characteristics of Brain Changes in Disease (Subproject No. 3: Histology to post-mortem MRI data fusion)
  • Open source, low cost Structured Illumination Microscope
  • Automated predictions of Age from 2D Ultrasound Images of the Developing Brain
  • Interactive counting of objects in microscopy images
  • MR Imaging of oxygen carriers in treatment of hypoxic tumours
  • Analysis of MR images using machine learning
  • Novel approaches for 3D fluorescence cellular imaging of thick specimens such as living brains
  • Actin cytoskeleton-mediated force generation in cells investigated by advanced (super-resolution) microscopy
  • Deep tissue nanoscopy: super-resolution imaging using adaptive optics STED
  • Quantitative Fluorescence Microscopy for Characterisation of theranostic agents
  • EEG movement artifacts
  • Adaptive Optics in Structured Illumination Microscopy
  • Novel tools integrating MRI and microscopy for neuroscience
  • Development of methods for imaging the cerebrovasculature in health and disease using MRI
  • Multi-modal registration of Connectome data
  • Synthesis and evaluation of novel theranostic platinum anti-cancer complexes
  • Multiclass survival analysis on Longitudinal perinatal imaging data using deep learning and state-of-the-art inference and learning methods
  • Virtual histology of the human brain using MRI: Informing the brain Connectome using tissue microstructure
  • Dissecting antibiotic resistance and bacterial biofilms via super-resolution imaging